Genetics

This skill enables querying the Open Targets Platform for drug target discovery, allowing users to search for gene targets, disease associations, known drugs, and evidence data. It provides Python helper functions to access tractability assessments, safety liabilities, clinical precedence, and genetic evidence for therapeutic target prioritization.

This skill provides guidance for querying the NHGRI-EBI GWAS Catalog, a comprehensive database of genome-wide association studies. It includes documentation on searching for SNP-trait associations, retrieving study metadata, accessing summary statistics, and integrating with Python for genetic epidemiology research and polygenic risk score development.

This skill enables querying the Ensembl genome database, a comprehensive resource for vertebrate genomic data maintained by EMBL-EBI. It supports gene information retrieval, DNA/protein sequence fetching, variant effect prediction using VEP, ortholog discovery, and coordinate mapping between genome assemblies for over 250 species.